![]() These biomarkers are part of the diagnostic research criteria for AD,. We found an excellent concordance of biomarker abnormality between assays of 97% for Aβ42 and 96% for both t-tau and p-tau.DiscussionThe high concordances between Elecsys and Innotest in this nonacademic, multicenter cohort support the use of Elecsys for CSF Alzheimer's disease diagnostics and allow conversion of results between methods.Īlzheimer's disease (AD) pathology is reflected in cerebrospinal fluid (CSF) by decreased levels of amyloid β(1–42) (Aβ42) and increased levels of phosphorylated tau (p-tau) and total tau (t-tau). Using Gaussian mixture modeling, cohort-specific cut-points were estimated at 1092 pg/mL for Aβ42, 235 pg/mL for t-tau, and 24 pg/mL for p-tau. ![]() Concordances between methods were assessed.ResultsBiomarker results strongly correlated between assays with Spearman's ρ 0.94 for Aβ42, 0.98 for t-tau, and 0.98 for p-tau. ![]() ![]() Amyloid β(1-42) (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau) were centrally analyzed with Innotest and Elecsys assays. IntroductionWe compared the automated Elecsys and manual Innotest immunoassays for cerebrospinal fluid (CSF) Alzheimer's disease biomarkers in a multicenter diagnostic setting.MethodsWe collected CSF samples from 137 participants in eight local memory clinics. ![]()
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